MULTIPLE VIRTUAL SCREENING APPROACHES FOR FINDING NEW HEPATITIS C VIRUS RNA-DEPENDENT RNA POLYMERASE INHIBITORS: STRUCTURE-BASED SCREENS AND MOLECULAR DYNAMICS FOR THE PURSUE OF NEW POLY PHARMACOLOGICAL INHIBITORS

Abstract The RNA polymerase NS5B of Hepatitis C virus (HCV) is a well-characterised drug target with an active site and four allosteric binding sites.This work presents a workflow for virtual screening and its application to Drug Bank screening targeting the Hepatitis C Virus (HCV) RNA polymerase non-nucleoside binding sites.Potential polypharmacol

Clutch components rotating at high speed remain under the influence of high centrifugal forces.Therefore at the high rotational speeds flywheel is subjected to extreme forces that may cause severe cracks and breakages.Burst test validates the mechanical robustness of the flywheel under various Food Storage rotational speeds.In this study comparativ

Achieving higher efficiency and better quality production with appropriate irrigation regimes in silage maize cultivation in soils mixed with urban sludge is a requirement of sustainable agriculture.Therefore, a two-year field study was carried out with three replicates with four different sewage sludge doses (D0: 0 t/ha, D1: 30 t/ha, D2: 60 t/ha,